Increasingly more diseases are recognized as multi-organ diseases, and the interaction between organ systems plays a crucial role in the pathophysiology of various diseases. While traditional basic and clinical research focuses on single organs, there is increasing evidence that these conventional organ-centered models must be complemented with an integrated view of the interactions between different organs to understand the progression of multi-organ diseases.

To make existing and continuously accumulating clinical and research results from organ crosstalk research projects accessible for and reusable by others, our interdisciplinary team will employ a holistic approach to address current limitations that prevent the linking,
sharing, and processing of clinical and research data from different research centers. Within the proposed focus areas of this ERS prep fund project, small interdisciplinary workgroups of experts from both faculties will tackle this fundamental gap in modern data science for clinical research, and individual research questions to (1) generate preliminary results, publications, and third-party funding and (2) identify expertise gaps and recruit additional partners.

Involved PIs

• Prof. Joachim Jankowski
  Institute for Molecular Cardiovascular Research
• Prof. Klaus Wehrle
  Lehrstuhl für Informatik 4 (Kommunikation und verteilte Systeme)
• Prof. Oliver Pabst
  Lehrstuhl für Molekulare Medizin (IMM)
• Juniorprof. Sandra Geisler
  Data Stream Management & Analysis (DSMA)
• Prof. Christian Trautwein
  Lehrstuhl für Innere Medizin (mit dem Schwerpunkt Gastroenterologie und Stoffwechselkrankheiten)
• Juniorprof. Michael Schaub
  Juniorprofessur für Computational Network Science (NetSci)
• PhD Kjong-Van Lehmann
  JRC for Computational Biomedicine
• Prof. Holger Hoos
  Artificial Intelligence Methods (AIM)

Our Team

• Johannes Lohmöller
• Jan Pennekamp
• Klaus Wehrle (PI)

Funding

PFExC005. Funded by the Excellence Initiative of the German federal and state governments.