This file was created by the TYPO3 extension bib --- Timezone: UTC Creation date: 2025-04-02 Creation time: 06-20-23 --- Number of references 2 article 2024_lohmoeller_sovereignty-survey Data & Knowledge Engineering 2024 5 1 151 Data ecosystems emerged as a new paradigm to facilitate the automated and massive exchange of data from heterogeneous information sources between different stakeholders. However, the corresponding benefits come with unforeseen risks as sensitive information is potentially exposed, questioning their reliability. Consequently, data security is of utmost importance and, thus, a central requirement for successfully realizing data ecosystems. Academia has recognized this requirement, and current initiatives foster sovereign participation via a federated infrastructure where participants retain local control over what data they offer to whom. However, recent proposals place significant trust in remote infrastructure by implementing organizational security measures such as certification processes before the admission of a participant. At the same time, the data sensitivity incentivizes participants to bypass the organizational security measures to maximize their benefit. This issue significantly weakens security, sovereignty, and trust guarantees and highlights that organizational security measures are insufficient in this context. In this paper, we argue that data ecosystems must be extended with technical means to (re)establish dependable guarantees. We underpin this need with three representative use cases for data ecosystems, which cover personal, economic, and governmental data, and systematically map the lack of dependable guarantees in related work. To this end, we identify three enablers of dependable guarantees, namely trusted remote policy enforcement, verifiable data tracking, and integration of resource-constrained participants. These enablers are critical for securely implementing data ecosystems in data-sensitive contexts. Data sharing; Confidentiality; Integrity protection; Data Markets; Distributed databases internet-of-production; coat-ers; vesitrust; health https://www.comsys.rwth-aachen.de/fileadmin/papers/2024/2024-lohmoeller-data-sovereignty-survey.pdf Elsevier 0169-023X 10.1016/j.datak.2024.102301 1 JohannesLohmöller JanPennekamp RomanMatzutt Carolin VictoriaSchneider EduardVlad ChristianTrautwein KlausWehrle article 2023-circres-wu-comp-ecosystem Circulation research 2023 4 14 132 8 1084-1100 The identification of mediators for physiologic processes, correlation of molecular processes, or even pathophysiological processes within a single organ such as the kidney or heart has been extensively studied to answer specific research questions using organ-centered approaches in the past 50 years. However, it has become evident that these approaches do not adequately complement each other and display a distorted single-disease progression, lacking holistic multilevel/multidimensional correlations. Holistic approaches have become increasingly significant in understanding and uncovering high dimensional interactions and molecular overlaps between different organ systems in the pathophysiology of multimorbid and systemic diseases like cardiorenal syndrome because of pathological heart-kidney crosstalk. Holistic approaches to unraveling multimorbid diseases are based on the integration, merging, and correlation of extensive, heterogeneous, and multidimensional data from different data sources, both -omics and nonomics databases. These approaches aimed at generating viable and translatable disease models using mathematical, statistical, and computational tools, thereby creating first computational ecosystems. As part of these computational ecosystems, systems medicine solutions focus on the analysis of -omics data in single-organ diseases. However, the data–scientific requirements to address the complexity of multimodality and multimorbidity reach far beyond what is currently available and require multiphased and cross-sectional approaches. These approaches break down complexity into small and comprehensible challenges. Such holistic computational ecosystems encompass data, methods, processes, and interdisciplinary knowledge to manage the complexity of multiorgan crosstalk. Therefore, this review summarizes the current knowledge of kidney-heart crosstalk, along with methods and opportunities that arise from the novel application of computational ecosystems providing a holistic analysis on the example of kidney-heart crosstalk. disease progression; ecosystem; heart; kidney; multimorbidity coat-ers Online en 10.1161/CIRCRESAHA.123.321765 1 ZhuojunWu JohannesLohmöller ChristianeKuhl KlausWehrle JoachimJankowski